Arcuri was last seen in Boca Raton, Florida on November 22, 1980. She has never been heard from again. She left her clothes, jewelry, keys, checkbook and $750 in cash at her home, and her family stated it would be uncharacteristic of her to abandon her children. She lived in the 1300 block of southwest 14th Street at the time of her disappearance. One of her children was at college, one had moved out of the family home and married, and the two youngest ones were still at home.

Arcuri was separated from her husband and in the process of a divorce, but she still worked for him at A and B Autoparts in Delray Beach, Florida. She allegedly told friends and her daughter that her husband had bound her hands, threatened her with a gun and attempted to strangle her some time before her disappearance. Her husband denied these allegations. He has never been named a suspect in her disappearance.

Arcuri's disappearance remains unsolved.