Lueth was last seen at her rented house in the 1100 block of Eureka Street in Lansing, Michigan on November 11, 2008. She was getting a second bachelor's degree in horticulture at Michigan State University; her previous degree was in botany. She disappeared after she took the bus home from class. Lueth was subletting an apartment on the floor below her to a friend, and spoke to him between 5:30 and 6:00 p.m. She was concerned because she'd broken up with her live-in boyfriend and he had just moved out, so her rental costs would increase. She said she planned to sell her truck and take a part-time waitress job to make ends meet. Lueth's friend said she seemed happy during the conversation. After she left her friend's apartment, he didn't hear any noise from upstairs. She was supposed to attend at 6:30 p.m. class at a greenhouse half a mile from home, but never showed up. She has never been heard from again. Lueth may have been carrying a white three-ring binder at the time of her disappearance.

Lueth's family reported her missing after they couldn't get in touch with her and all the calls to her phone went to voice mail; this is uncharacteristic of her. She left her cat locked inside her apartment, as well as a covered pot of food on the stove. It looked as if she had stepped out and planned to return within a short time, but never did. Her loved ones describe her as a reliable, responsible woman who wouldn't have abandoned her pet or left without warning. She was a very good student and planned to apply to a graduate program at Cornell University.

Lueth attended St. Clair High School and later St. Clair County Community College. Her father raised her as a single parent starting when she was twelve years old. Her family believes foul play was involved in her disappearance, and the police also believe she was murdered, possibly at the hands of someone she knew. Her case remains unsolved.